Is CBD Oil Effective in the Treatment of Multiple Sclerosis?
Multiple Sclerosis often referred to as MS, can in some diagnosis be a debilitating autoimmune disease that impacts the spinal cord and the brain. The severity of MS symptoms varies dramatically between patients and over time. Many sufferers find that the symptoms of the disease get worse over time.
Multiple Sclerosis most common characterisation is that the condition causes major issues with mobility. This can be as serious as total paralysis or numbness in the sufferer’s limbs. MS sufferers also commonly have symptoms such as fatigue, muscle spasms, pain, cognitive impairment and sometimes problems with their vision.
The true cause of Multiple Sclerosis remains unknown, but there is extensive research being carried out to try to ascertain the precise cause of the disease. There have been studies on animals using experimental autoimmune encephalomyelitis (EAE), the animal equivalent of MS in humans, revealed that T cells crossing the blood brain barrier which triggered neuroinflammation. In turn, this caused the destruction of myelinated neuronal cells and produced symptoms of paralysis.
What are the different types of Multiple Sclerosis?
The body’s nervous system is surrounded in a protective coating known as the myelin sheath. Multiple Sclerosis causes damage to this protective layer as the immune system attacks it. That leaves the nerve cells exposed and scarred.
There are four different variations of multiple sclerosis.
Progressive-Relapsing (PRMS) – this is the rarest form of MS. The disease gets worse over time and flares up in relapses. After experiencing one of these attacks, the chance of a full recovery is not known.
Secondary-Progressive (SPMS) – With SPMS, the symptoms deteriorate between flare ups even if a flare up doesn’t actually occur.
Relapsing Remitting (RRMS) – This is the most common form of Multiple Sclerosis and accounts for approximately 80% of cases. It is the least debilitating of all the variations of MS. Relapses occur when the symptoms flare up and are followed by long recovery times.
Primary Progressive (PPMS) – PPMS gradually gets worse from the onset of the condition, flare ups are not common in those suffering from PPMS.
What is CBD?
Cannabidiol which is commonly referred to as CBD or CBD oil, is a non-psychoactive element of the Cannabis plant. CBD is known to have anti-inflammation properties which makes it a useful tool in treating many chronic conditions. There are over 150 cannabinoids contained within the cannabis plant and CBD is one of the most active compounds. It is THC that is the psychoactive element of the cannabis plant and is outlawed across most of the world.
Multiple Sclerosis and CBD Oil
Cannabidiol, commonly known as CBD is the primary non-psychoactive element of the cannabis plant. CBD is known to exhibit anti-inflammatory effects that can assist in treating conditions that are either caused or enhanced by prominent inflammation. CBD is also known to have neuroprotective effects and may be a useful tool in treating suspected autoimmune diseases, conditions such as ulcerative colitis and Alzheimer’s disease.
Considering how little is truly known about Multiple Sclerosis, it was believed that CBD could also benefit MS patients. Over time, drugs including Sativex which is a cannabis oil consisting of primarily CBD and THC have been sporadically developed. Sativex is now widely prescribed around the world to MS patients who feel that their symptoms are not being effectively treated by traditional pharmaceuticals.
Clinical studies that have been conducted illustrate that patients receiving Sativex report a higher quality of life and a lower spasticity than they were experiencing prior to CBD oil treatment. The precise method of how CBD interacts with the appropriate mechanisms that cause MS remains unclear, more research needs to be undertaken to discover the exact manner of the interaction.
Cutting edge research at the University of South Carolina, studied the treatment of murine EAE using CBD oil to characterise previously unknown biochemical mechanisms that enables CBD to inhibit EAE symptoms which are very similar to MS.
The research project induced EAE in groups of female mice using the peptide MOG35-55 as an antigen. The mice were treated with either CBD oil or a controlled vehicle. The progression of the disease was tracked using clinical measurements associated with various symptom expressions. The scores were measured on a scale of 0-6. The average score for each group of mice was calculated daily and the scores for the mice who were treated with CBD and the control group treated mice were compared to assess the effectiveness of the CBD treatment.
The mice treated with the controlled vehicle developed EAE at a steady rate, with a maximum mean clinical score of 4.1 throughout the study. A clinical score of 4 in the study equates to a state of tetra-paralysis. The mice that were treated with CBD experienced a slower onset of symptoms and at their peak, the clinical score of the symptoms that was recorded was 2.2. The clinical score of 2.2 only indicates the only partial paralysis of the limbs.
This provides a confirmation that CBD treatment has a clear effect on EAE. The researchers conducted in vivo, and ex vivo tests to try to decipher exactly what biochemical mechanisms were responsible for the effectiveness of the CBD treatment.
It is understood that EAE in mice is triggered by TH1 and TH17 cells.
A survey carried out by the MS Society discovered that 20% of people who were diagnosed with MS had used Cannabis to help to ease their symptoms.
A study carried out in 2018 discovered that CBD improved the mobility in people with Multiple Sclerosis.
Can CBD Reduce Multiple Sclerosis Symptoms?
There is evidence that suggests that CBD could ease Multiple Sclerosis symptoms for some MS patients. The science behind these benefits is still being investigated. The available data indicates that cannabis product with approximately a 1:1 THC to CBD ratio used as an oral spray may reduce pain and muscle spasms in Multiple Sclerosis patients.
There is still a tremendous amount of research that needs to be carried out to determine whether over the counter CBD products such as CBD oils, CBD tablets, CBD patches and CBD vapes can provide MS sufferers with a symptom relief and to understand whether there is any prospective harm in using CBD.
The Need for Clinical Studies
An article that was published by the medical journal Frontiers in Neurology discussed whether CBD has the potential to provide positive pharmacological effects. This is because CBD is an anti-inflammatory, antiemetic, antioxidative and neuroprotective. The article also states that CBD is considered to be safe and it does not alter the user’s heart rate.
When it comes to Cannabis and Multiple Sclerosis, only cannabis-based products that contain CBD & THC have been subjected to clinical studies. Only cannabis with a 1:1 ratio of CBD to THC, some examples of a higher THC content have been undertaken too. These clinical studies have shown that cannabis can reduce muscle spasticity and pain in those who suffer from Multiple Sclerosis.
There have yet to be any clinical studies that demonstrate whether cannabis oils containing solely CBD have any tangible benefits to those who have MS. All the studies that have taken place thus far have used different preparations that contain both THC and CBD or THC by itself.
What are the Side Effects of CBD?
CBD is well tolerated, but it can cause a few minor side effects. Possible side effects include dry mouth, diarrhoea, fatigue and reduced appetite. There are also a few medications that CBD can interact with, these include blood thinning drugs. For further information, please read our comprehensive breakdown of the side effects of CBD.
It is always advisable to speak to your doctor if you have any concerns about trying CBD.
How can I take CBD?
CBD can be consumed in an array of different delivery methods. The bioavailability of the CBD varies between the different delivery methods and this can be a crucial factor when assessing the efficacy of a CBD product.
CBD tincture oils are the most commonly used CBD product. With a CBD tincture you simply place drops of the CBD oil underneath your tongue for around 30 seconds. The CBD is then absorbed into the bloodstream without having to pass through the digestive system. After using CBD oil, the user can expect to begin to feel the effects after 15-25 minutes.
Many MS patients elect to use CBD oil as the effects can be felt quickly and there is a tangible benefit.
CBD patches are an extremely effective way of consuming CBD. When using a CBD patch, you simply apply the CBD patch the top of your arm for a 24 hours period and the CBD is released gradually throughout the day. One of the excellent things about using a CBD patch is that it bypasses your liver, lungs and stomach which are all parts of the body that filter down cannabinoids. The resulting effect is enhanced, and CBD patches seem to be among the most effective CBD products on the market.
CBD Drinks are a new way of consuming CBD and they are affordable and easy to incorporate into your daily life. CBD drinks can easily replace your daily soft drink and can provide you with the benefits of CBD.
CBD tablets are a convenient and safe way of taking CBD. With tablets you know exactly how much CBD you are taking, and this standardised dosing option means that many people choose to use CBD tablets over a CBD oil because it is easier to take.
CBD vapes are also great ways to consume CBD. With the absence of the negative effects of smoking tobacco, modern CBD vapes enable the user to take CBD in a manner that is convenient and enjoyable to use.